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The following list gives examples of ongoing research projects within statistics and cancer epidemiology at SBR
Multi-state models for late effects of childhood cancer
Statistical localization of brain tumors
Familial aggregation of cancer
Analysis of high dimensional data
Multi-state models for late effects of childhood cancer
The objective of the project is to apply and develop statistical methods for analysis of late effects of childhood cancer and cancer treatment, such as diabetes and ischemic heart disease. We consider advanced regression models to study both competing and recurrent events.
Contact:
Luise Cederkvist Kristiansen, luiseck@cancer.dk
Statistical localization of brain tumors
The objective of the project is to apply and compare different statistical methods and hereby to investigate if brain tumors (glioma) tend to be located certain parts of the brain. Furthermore, the project aims at studying whether gliomas tend to cluster in areas of the brain which are exposed to most of the energy from radiation from mobile phones.
The project is based on data from the international INTERPHONE study (http://interphone.iarc.fr/).
Contact:
Kathrine Grell, grell@cancer.dk
Familial aggregation of cancer
The objective of the project is to investigate familiar aggregation of cancer by means of advanced statistical methods. The project focuses on incidence of disease in twins, siblings, parents and cousins in order study familial aggregation, and seeks to quantify and distinguish the contribution from both the shared environment and the genes.
Contact:
Klaus Kaae Andersen, klaus@cancer.dk
Analysis of high dimensional data
High dimensional data is a common challenge within cancer research. SBR have experience with analysis of high dimensional in association to the incidence and prognosis of cancer. Currently, SBR is collaborating with researchers from department of oncology, Herlev Hospital, on several projects concerning microRNA measurements as biomarkers for incidence and prognosis of cancer.
Contact:
Christian Dehlendorff, chrdehl@cancer.dk
Cancer epidemiology
The research activities are primarily focused on urologic cancer, notably prostate cancer; the relationship between diabetes mellitus and cancer; and descriptive and analytical register studies of a number of cancer diseases based on data from the Danish Cancer Registry and other nationwide registers. The Department is represented by Søren Friis in the Danish Multidisciplinary Cancer Group for Prostate Cancer (DAPROCA), the Steering Committee of the Clinical Quality Database for Prostate Cancer (DaProCaData), and the international forums International Diabetes Cancer Research Consortium (DCRC), the International Lung Cancer Consortium (ILCCO), the European Prospective Investigation into Cancer and Nutrition Group for bladder, and the Chemical & Environment Working Group within the European Code Against Cancer Program, International Agency for Research on Cancer.
Contact:
Søren Friis, friis@cancer.dk
Pharmacoepidemiology
Pharmacoepidemiological research constitutes a key activity in the Department, including two current projects on associations between a number of drugs and risk of prostate cancer. The Department undertakes or contributes to an array of studies focusing on drugs with potential chemopreventive effect, e.g. aspirin and other NSAIDs, as well as drugs acting as potential risk factors for cancer, e.g. insulin. A new research field is the influence of commonly used drugs on the prognosis of a number of cancer diseases. Among other new areas of interest are evaluation and improvement of existing pharmacoepidemiological methods, and investigation of chemopreventive effects demonstrated in laboratory studies by pharmacoepidemiological studies of human populations.
Contact:
Søren Friis, friis@cancer.dk